We address core gaps in healthcare, education and psychosocial support in the most neglected and under-served communities, last mile communities, where there are no services, no development, no employment, just about nothing. We serve these last mile communities.” 

The natural, untouched beauty of the villages belies not only the abject poverty, but also the strength and resilience of the ordinary people therein. We believe that local people, especially women, with local challenges and experiences, are best placed to meet the needs of our beneficiaries in the communities we serve. This is why, rooted at the core of our approach, is a peer-led solution, which we deploy across our three flagship programmes to ensure beneficiaries access the appropriate care and treatment.

We recruit, train and support a network of inspiring local women to bring systemic change to their families and their communities. We call them Mentor Mothers; they provide proactive, ‘door to door’ care, preventing, identifying and dealing with a myriad of issues linked to maternal and child health including prevention and treatment of HIV and TB, nutrition, sex education and vaccine access and awareness before they become problematic.

The smiles on their faces don’t reflect the harsh realities of their daily work, walking many kilometres in harsh conditions to go door-to-door to each and every household in the village, bringing health education and advice to those households, their bright green shirts have become bright beacons of hope within the communities. The challenges they face in their work demand that innovation becomes par for the course.

OUR WORK

ENABLE – MENTOR BROTHERS

The Enable – Male Champions for Change aims to engage, inform, equip, empower men and transform them to actively protect, promote and support the health and well-being of themselves, their partners and their children.

MORE INFO

ENABLE – MENTOR MOTHERS

Our Mentor Mothers provide in-home healthcare and support that is transforming the lives of vulnerable mothers and babies, and building the foundation for a healthier future for the whole community in Mankosi, South Africa.

MORE INFO

BRIGHT START

70% of children who live in HIV-affected households experience developmental delays and cognitive deficit. This project kick-starts cognitive development for vulnerable children in South Africa.

MORE INFO

BETTER TOGETHER

AIDS is now the leading cause of adolescent deaths in Africa. This is a project working with teenagers living with HIV as they begin to manage their own treatment and develop new relationships, while still often facing stigma.

MORE INFO

ENABLE

Our Mentor Mothers provide in-home healthcare and support that is transforming the lives of vulnerable mothers and babies, and building the foundation for a healthier future for the whole community in Mankosi, South Africa.

MORE INFO

BRIGHT START

70% of children who live in HIV-affected households experience developmental delays and cognitive deficit. This project kick-starts cognitive development for vulnerable children in South Africa.

MORE INFO

BETTER TOGETHER

AIDS is now the leading cause of adolescent deaths in Africa. This is a project working with teenagers living with HIV as they begin to manage their own treatment and develop new relationships, while still often facing stigma.

MORE INFO

THOUGHT LEADERSHIP

Letterhead-template-03

One to One Africa presents at the 2025 SAAIDS Conference in Johannesburg. 

At the 2025 AIDS Conference, Thandi Matikinca showcased One to One Africa’s role in advancing community health and improving local health outcomes through innovative, community-based programmes. One to One Africa is grateful for the opportunity to share our insights and experiences as we work to achieve a sustainable impact in the fight against the epidemic.

LEARN MORE

528219380_737867702213422_1666583495723383548_n

IBe inspired by how music is strengthening community health and connection!

CHIME (Community Health Intervention through Musical Engagement) & One to One Africa & Perinatal Mental Health Project delivered a 1 hour interactive webinar on 6th August 2025 entitled ‘A Story of Collaborative Music-Making in the Eastern Cape, South Africa’. The webinar explored the development of CHIME and its implementation in maternal and child health programmes in the Eastern Cape of South Africa.

WATCH HERE

533088974_745176474815878_2883482139207996783_n
One to One Africa team proudly joined the Expert Forum hosted by Siyakholwa Development Foundation and aRe Bapaleng, diving deep into the urgent issue of stunted growth among children in the Eastern Cape.
With decades of grassroots experience and a commitment to community-led solutions, OTOA brought powerful insights to the table—championing integrated, evidence-based approaches to child health, nutrition, and early development.

LEARN MORE

ONE TO ONE AFRICA: GET INVOLVED

IMG_8196

Help us restore the health of last-mile communities. One to One Africa is a South African NPO that provides critical health services to last-mile rural communities of South Africa. In need of a new rural clinic, all donations will secure best-of-class healthcare to the most vulnerable communities in South Africa. DONATE HERE

Team-Flood_Coaching_Mandela_Banner

One to One Africa is committed to 𝗘𝗡𝗔𝗕𝗟𝗜𝗡𝗚 𝗠𝗮𝗻𝗱𝗲𝗹𝗮’𝘀 𝗵𝗼𝗽𝗲 𝗳𝗼𝗿 𝗰𝗵𝗶𝗹𝗱𝗿𝗲𝗻 through delivering life-saving health interventions to babies and children in last-mile communities within the Eastern Cape province of South Africa. Mandela’s home district falls into this category, with the OR Tambo District being the headquarters for our ENABLE programme. In honour of President Mandela donate, HERE.

Header-Image_1280x853px_Mother+Babies

ITHEMBA CIRCLE OF HOPE – a network of women committed to supporting women in vulnerable communities. We have launched a network of women who share the same human values of wanting to ensure that women everywhere have the same opportunities to build the safe, healthy and stimulating home environment that children need to thrive. We have launched a Cape Town, Johannesburg and London chapter. LEARN MORE.

SUBSCRIBE